The contribution of Fcgr4 macrophages to metabolic inflammation resolution
We previously found that weight loss in obesity promotes the accumulation of a novel macrophage subtype in the visceral adipose tissue, and that these cells disappear with weight regain. This project aims at understanding the function, origin and fate of these novel macrophages and their contribution to healing of obesity-related diseases.
The effects of weight loss and regain on immune progenitors
Progenitor cell responses are tightly regulated by metabolic processes and nutrient availability, both of which change dramatically in weight loss and regain. Changes occurring at the progenitor level affect inflammation in many tissues at the same time. We found that both weight loss and weight regain reprogram immune progenitors long-term. This project aims at determining how weight fluctuations influence immune progenitors to promote healing immunity in weight loss and heightened inflammation in weight regain.
The effects of weight loss and regain on psoriasis and its relationship with cardiovascular disease
Obesity is associated with a more severe manifestation of psoriasis, and weight loss improves the skin inflammation. Moreover, psoriasis patients have increased risk of cardiovascular diseases. This project aims at understanding the relationship between these comorbid conditions, in hopes of identifying pathways that can be targeted to heal multiple obesity-related diseases at the same time.
We previously found that weight loss in obesity promotes the accumulation of a novel macrophage subtype in the visceral adipose tissue, and that these cells disappear with weight regain. This project aims at understanding the function, origin and fate of these novel macrophages and their contribution to healing of obesity-related diseases.
The effects of weight loss and regain on immune progenitors
Progenitor cell responses are tightly regulated by metabolic processes and nutrient availability, both of which change dramatically in weight loss and regain. Changes occurring at the progenitor level affect inflammation in many tissues at the same time. We found that both weight loss and weight regain reprogram immune progenitors long-term. This project aims at determining how weight fluctuations influence immune progenitors to promote healing immunity in weight loss and heightened inflammation in weight regain.
The effects of weight loss and regain on psoriasis and its relationship with cardiovascular disease
Obesity is associated with a more severe manifestation of psoriasis, and weight loss improves the skin inflammation. Moreover, psoriasis patients have increased risk of cardiovascular diseases. This project aims at understanding the relationship between these comorbid conditions, in hopes of identifying pathways that can be targeted to heal multiple obesity-related diseases at the same time.